Non-melanoma skin cancers (NMSC) are the most common human cancers, particularly in the

Caucasian population. The possible evolution of actinic keratoses (AKs) into invasive squamous cell carcinomas (SCC) makes their treatment and monitoring essential. AKs are typically monitored before and after treatment only through a visual analysis, lacking a quantitative measure to determine treatment effectiveness. Near-infrared spectroscopy (NIRS) is a non-invasive measure of the relative change of oxy-hemoglobin and deoxy-hemoglobin (O2Hb and HHb) in tissues. This research line is focused on the quantitative analysis of the vascularization before and after various kinds of treatment (i.e. topical treatment). In particular, it is aimed at determining if a time and frequency analysis of the NIRS signals acquired from the skin lesion before and after a topical treatment, using an ice pack to stimulate vasculature reactivity, can highlight quantitative differences in the AK skin lesion area.


  • Kristen M. Meiburger (Assistant Professor with time contract (RTD/a))
  • Silvia Seoni (Ph.D. Student)
  • Collaborators:

  • Prof. Paola Savoia, Elisa Zavattaro, Federica Veronese - University Hospital Maggiore della Carità, Novara

  • Recent publications:

  • Non-Invasive Analysis of Actinic Keratosis before and after Topical Treatment Using a Cold Stimulation and Near-Infrared Spectroscopy
      Silvia Seoni, Paola Savoia,Federica Veronese,Elisa Zavattaro,Vanessa Tarantino, and Kristen M. Meiburger
  • Non-invasive analysis of actinic keratosis using a cold stimulation and near-infrared spectroscopy
      Silvia Seoni, Federica Veronese, Vanessa Tarantino, Elisa Zavattaro, Massimo Salvi, Nicola Michielli, Bruno De Santi, Filippo Molinari, Paola Savoia, Kristen M. Meiburger
      2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)