There is a strict relationship between workload, quality of care, and clinical outcomes. Consequently, the quantification and reduction of physician’s workload is an issue worth of being effectively faced and solved. Given the high complexity of the clinical domain, the analysis of possible solutions is not a trivial task. For this reason, modeling and simulation tools could provide an interesting way of analyzing the physicians’ workload. We investigated, by means of process modeling tools and agent-based simulations, the impact of the changes in the organization on the physicians’ workload of the center for patients with thrombotic and bleeding disorders of the Oncologic Department of Città della Salute e della Scienza di Torino. A four-step procedure was applied including data collection, analysis of the clinical processes carried out in the center through process modeling, design of an agent-based model, and simulation of different scenarios to evaluate their effects on the workload of physicians.